I have asked many people, some have said yes others have said no. I know you aren't allowed to be on anti depressants but that's not what I'm asking. When I piss in a cup, will it come back saying positive for zoloft? Regardless, the test would have to be very specific for the metabolites of sertraline itself, as serotonin is native to the body. Many websites I've visited have a list of what they test for and Zoloft wasn't among them. And thus you'd then have to test for every SSRI, SNRI, or MAOI out there. To be honest, I have no idea about anything in the military, nor do they teach us that. I was just going on the COMMON SENSE that a test for that drug would be highly unlikely. 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Aug 18, 2016. ABSTRACT Urine drug screening is a common way to test for compliance with medications having high abuse potential. False-negatives and. This article is an interesting point I wanted to make around the question does Zoloft work for anxiety? It could help lots of people avoid significant problems that make that anxiety worse in the long run. Although it’s routinely prescribed to people who have been diagnosed with anxiety disorders or panic disorders, there are a lot of questions around whether Zoloft makes people feel better or if the side-effects are to much of a gamble, especially in low-grade anxiety cases. So let’s take a look at what Zoloft is, how it works, and the fascinating point I’ve found around whether it’s the right first choice for people suffering with anxiety. Zoloft belongs to a group of antidepressants known as selective serotonin re-uptake inhibitors, usually referred to as SSRI’s. 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