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Also, a clinically identified side effect of zoloft is anxiety and marijuana obviously can create some sort of paranoia, so mixing the two is almost a sure recipe for serious anxiety and possibly anxiety attacks. i'm on zoloft from the past 4 months and this weekend i smoked with my friends and it was a very pleasant experience.i felt really good and had much fun.though, my opinion is that u feel bad or good depending on your actual state when u depends about every person I don't know if it was due to the marijuana but.. my personal experience makes it seem as if each alcoholic drink is twice as strong, limiting my alcohol tolerance. I was convinced my boyfriend wanted me to smoke because in was laced with a date rape drug... zoloft is a seratonin inhibitor, designed with the intention of keeping your body from feeling the physical effects of sadness. according to my physician, who prescribed me zoloft, and simply to the label on the bottle, alcohol and zoloft she be mixed with extreme care and without excess. I've been taking Zoloft for about 6mo.s and never smoke. I had a worse trip than the worst trip you could have on X. aggy, you said that zoloft has no reaction with alcohol or marijuana and that is untrue and is a dangerous assumption. I had been a heavy daily user of marijuana for many years and sometime last year was prescribed Zoloft for anxiety during some personal issues. I smoked weed for the first time with zoloft recently and I had completely nothing go wrong. Upon taking the Zoloft, my anxiety was gone, but I became extremely angry and aggressive which is completely out of character for me and had to discontinue it's use. IN fact before zoloft I usually am the one to have really bad highs and become ultra paranoid on weed any usually am done only after 2-3 tokes, i feal as if im going to die. While on zoloft however i smoked again to see if I would have the same problem because there was this one time that i did get high and was actually in great bliss. Zoloft smoking Can Zoloft Be Used To Stop Smoking -, Is smoking cannabis whilst taking sertraline anti depressant. - Quora Order zovirax Doxycycline 50 mg for cats Apr 29, 2013. "Better living through chemistry" isn't just a slogan I've been on antidepressants for 20 years, and can still remember exactly when the first one. 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