Warfarin (Coumadin) is the most commonly prescribed anticoagulant to prevent thromboembolisms in patients with atrial fibrillation, venous thromboembolism, and prosthetic heart valves. Providers must closely monitor the degree of anticoagulation in patients on warfarin using the international normalized ratio (INR). Many patients have an INR target range between 2 and 3 or between 2.5 and 3.5, depending on the indication for anticoagulant therapy, ensuring appropriate anticoagulation and avoiding thrombosis and bleeds. Providers must titrate warfarin doses appropriately and regularly review patients’ medications for possible interactions. A patient’s INR can increase or decrease with newly prescribed or discontinued medications. Retail health care providers are in an optimal position to monitor for drug interactions between warfarin and antibiotics because 80% to 90% of all antibiotics are prescribed in an outpatient setting. WHEN TO WORRY Prescribers must consider how adding and removing medications will affect a patient’s INR. cipro suspension Warfarin (Coumadin) can reportedly interact with more than 100 different medications from various classes. Nearly 30 million prescriptions are written annually for the vitamin K antagonist that has been the mainstay anticoagulant treatment for patients with atrial fibrillation and other cardiac arrhythmia conditions. It is important for patients on warfarin to maintain a consistent level of the drug in their body in order for it to work. However, many products—including prescription drugs, OTC medications, and herbal supplements—can alter the amount of warfarin in the body because of how they are metabolized or broken down. Pharmacists should make sure that patients taking the following drugs have their international normalized ratio (INR) checked more frequently. SSRIs Selective serotonin reuptake inhibitors (SSRIs) have been shown to increase bleeding risk in susceptible patients. There is also evidence of an additive increase in bleeding risk when SSRIs are used concurrently with other drugs that can cause bleeding, such as warfarin. “It does not appear necessary to avoid using SSRIs or other antidepressants in people taking warfarin, but the possibility of increased bleeding risk should be considered when selecting treatment for depression,” John Horn, Pharm D, and Philip Hansten, Pharm D, previously wrote in . Finasteride 5mg Does valtrex cause birth defects Warnings famciclovir for cats cost azithromycin uri coumadin and acupressure mats septra gram negative metformin and testosterone levels additional benefits. best place to order viagra Clin Ther. 2013 Apr;354425-30. doi 10.1016/j.clinthera.20. Epub 2013 Feb 28. Effect of azithromycin on anticoagulation-related outcomes in. Foods containing vitamin K affect how Coumadin works. medications amiodarone, propafenone; Antibiotics azithromycin Zmax, Zithromax, cefazolin Ancef, Using azithromycin together with warfarin may cause you to bleed more easily. You may need a dose adjustment based on your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. Switch to professional interaction data Nutrition and diet can affect your treatment with warfarin. Therefore, it is important to keep your vitamin supplement and food intake steady throughout treatment. Contact your doctor as soon as possible if you are taking these two medicines. You should watch for any unusual bleeding or bruising. Your bleeding times may need to be monitored and the dose of your blood thinner adjusted, or you may need to be switched to a different antibiotic. You should maintain good nutrition while on these medicines. This drug interaction may be more likely to occur if you are elderly or if you are taking larger doses of the antibiotic. Make sure that your doctor knows all of the medicines that you are taking. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first. Zithromax and coumadin ZITHROMAX® azithromycin dihydrate Drug Interactions Pfizer., Effect of azithromycin on anticoagulation-related outcomes in geriatric. Metoprolol tartrate 25 mg recall Prednisone 10mg Viagra 100 mgs Xanax fact sheet Prednisone and bleeding Interactions with Coumadin package insert. following list contains common medications that interact with warfarin Coumadin. Azithromycin Zithromax. Drug Interactions with Warfarin Med Cart Reference Guide Risk of. What medications can interact with warfarin Coumadin? - Sharecare Selected warfarin drug-drug interactions - GlobalRPH Combinations can significantly affect your warfarin Coumadin® blood thinning. Vibra-tabs. Vicodin. Vitamin K. Voriconazole. Xeloda. Zaroxlyn. Zithromax. viagra on medicare A Moderate Drug Interaction exists between Coumadin and Zithromax. View detailed information regarding this drug interaction. Pharmacotherapy. 1999 Jul;197902-8. Potential interaction between azithromycin and warfarin. Foster DR1, Milan NL. Author information 1College of.