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    The percutaneous absorption in rabbits of propranolol from an alcohol-based gel ointment was studied to find a possible formulation of a transdermal dosage form which achieves a systemic effect. Gel ointments containing 1% propranolol were prepared by mixing ethanol/propylene glycol (Et OH/PG, 2:1 v/v) with 0.6 g Carbopol 934 in different amounts of water. The sum of the volumes of water and Et OH/PG was kept constant. The amount of propranolol released from the gel ointment as a function of the Et OH/PG content showed a convex relationship, giving a maximum release around 45–55% Et OH/PG. The solubility data for propranolol in various (Et OH/PG)/water mixtures indicated that a content of about 55% Et OH/PG was required to dissolve 1% propranolol in the gel ointment. In the study of percutaneous absorption of propranolol in rabbits, a gel ointment of 55% Et OH/PG, which was prepared according to the solubility data mentioned above, gave a distinctly high plasma level as compared with an ointment containing 40% Et OH/PG and conventional ointments. The mean plasma level obtained using 55% Et OH/PG, about 60 μng/ml, was comparable to the levels used for therapeutic purposes in human. Inderal Propranolol Side Effects, Interactions, Warning. sildenafil risks Propranolol Gel DailyMed - PROPRANOLOL HYDROCHLORIDE- propranolol.
     
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