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Valtrex versus acyclovir

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    Valtrex versus acyclovir


    Nongenital herpes simplex virus type 1 is a common infection usually transmitted during childhood via nonsexual contact. Most of these infections involve the oral mucosa or lips (herpes labialis). The diagnosis of an infection with herpes simplex virus type 1 is usually made by the appearance of the lesions (grouped vesicles or ulcers on an erythematous base) and patient history. However, if uncertain, the diagnosis of herpes labialis can be made by viral culture, polymerase chain reaction, serology, direct fluorescent antibody testing, or Tzanck test. Other nonoral herpes simplex virus type 1 infections include herpetic keratitis, herpetic whitlow, herpes gladiatorum, and herpetic sycosis of the beard area. The differential diagnosis of nongenital herpes simplex virus infection includes aphthous ulcers, acute paronychia, varicellazoster virus infection, herpangina, herpes gestationis (pemphigoid gestationis), pemphigus vulgaris, and Behçet syndrome. Oral acyclovir suspension is an effective treatment for children with primary herpetic gingivostomatitis. amoxicillin clavulanate In the last five years there has been very limited new evidence on the effectiveness of oral antivirals in children with chickenpox, pregnant women with herpes simplex virus, pregnant women with herpes zoster, or pregnant women with chickenpox. In children with chickenpox acyclovir was shown to be effective, although clinical significance in otherwise healthy children is questionable. No evidence on the comparative effectiveness of valacyclovir in this population was identified. There is RCT data supporting efficacy of both acyclovir and valacyclovir in pregnancy for suppression of recurrent genital herpes. Although available data are reassuring as to the safety of valacyclovir in pregnancy, there is substantially more experience with acyclovir. Recent practice guidelines for the treatment of both chickenpox and genital herpes in pregnancy consistently recommend acyclovir for certain clinical scenarios. Many of these guidelines also present valacyclovir as an option.

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    Valtrex versus acyclovir

    Breakthrough herpes episodes occur even with high-dose antivirals., Acyclovir versus Valacyclovir for Herpes Virus in Children and. - Cadth

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