Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, c GMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased c GMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH. zoloft mayo The length of time Viagra lasts for will vary from person to person, but it can work for up to 5 hours at a time. This doesn’t mean you will have an erection for 5 hours, it means you will be able to get them easier during this time. Most men will find, that the effects of the pill will start to wear off 2 to 3 hours after first taking it. 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United States Food and Drug Administration, 8 July 2005. viagra deutschland Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension PAH. Sildenafil. Nov 26, 2018. 4 pack of 50mg sildenafil citrate film-coated tablets. Efficacy and safety of sildenafil citrate Viagra for the treatment of erectile dysfunction in. When a man is sexually excited, the penis rapidly fills with more blood than usual. With this extra flow of blood, the penis then expands and hardens. After the man is done having sex, this extra blood flows out of the penis back into the body. In an opposite extreme situation, if an erection lasts for a long time (more than 6 hours), it can permanently damage your penis. You should call a doctor immediately if you ever have a prolonged erection that lasts more than 4 hours. Therefore sexual activity may not be advisable for people who have heart problems. Before you start any treatment for erectile dysfunction, ask your doctor if your heart is healthy enough to handle the extra strain of having sex. If you have chest pains, dizziness or nausea during sex, stop having sex and immediately tell your doctor you have had this problem. This is called erectile dysfunction if it becomes a frequent problem. Erectile dysfunction is a serious problem that can affect both the young and the old, involving psychological causes in some cases. Among other treatments that are nowadays available for erectile dysfunction, Viagra was the first. Some conditions and medicines interfere with the natural erection process. Erectile dysfunction, defined today as the inability to attain and maintain an erect penis with sufficient rigidity for sexual intercourse, has become an increasingly common complaint that affects 140 million men worldwide. So Viagra stands out as the pioneer of drugs that treat erectile dysfunction, for twenty years. Sildenafil citrate was the first oral agent to be introduced for the treatment of erectile dysfunction, thanks to the researchers from Pfizer. Sildenafil is the active substance of Viagra, while Viagra is the commercial name. Teva’s generic Viagra has launched already in December 2017 in the United States. Risk factors for developing erectile dysfunction include age, diabetes, hypertension, obesity, lack of exercise, dyslipidemia, smoking, depression, lower urinary tract symptoms, and pelvic surgery. Sildenafil is a highly selective inhibitor of PDE type 5 and enhances NO-mediated relaxation of human corpus cavernosum. Pfizer recently started to sell the new generic version of Viagra. Sildenafil is a common medication used to stimulate erections in men with erectile dysfunction (ED) and treat certain heart conditions. Many factors can influence how long Viagra takes to start working. In general, Viagra takes about 30 minutes to produce noticeable effects. 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