Hello, I had a severe allergic reaction two weeks ago to an unknown substance, and they gave me prednisone thru IV at the ER. Then they sent me home with a 15 day taper of tablets...60mg for 5 days, 40mg for 5 days, and finally 20 mg for 5 days. more »Hello, I had a severe allergic reaction two weeks ago to an unknown substance, and they gave me prednisone thru IV at the ER. Then they sent me home with a 15 day taper of tablets...60mg for 5 days, 40mg for 5 days, and finally 20 mg for 5 days. They did not tell me ANYTHING about this drug, and had I known the awful way it would make me feel, I would have refused it. Throughout the time I was taking the pills, I had terrible anxiety (which, I usually have anxiety, but nothing as intense as this), crying spells, heart palpitations, trouble breathing, you name it! I spoke to my doc and some pharmacists who told me that these were all side effects of the prednisone and should subside once the drug is out of my system. 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