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    Objective - To determine pharmacokinetics and oral bioavailability of metformin in healthy horses. Procedures - 6 g of metformin was administered 3 times IV and PO (fed and unfed) to each horse, by use of a crossover design, with a 1-week washout period between treatments. Plasma metformin concentration was determined via high-pressure liquid chromatography. Results - Mean ± SD distribution half-life of metformin following IV administration was 24.9 ± 0.4 minutes with a volume of distribution of 0.3 ± 0.1 L/kg. Mean area under the curve was 20.9 ± 2.0 h·μg/m L for IV administration; PO administration resulted in area under the curves of 1.6 ± 0.4 h·μg/m L in unfed horses and 0.8 ± 0.2 h·μg/m L in fed horses. Bioavailability was determined to be approximately 7.1 ± 1.5% in unfed horses and 3.9 ± 1.0% in fed horses. The maximal concentration following PO administration in unfed horses was 0.4 ± 0.1 μg/m L with a time at maximal concentration of 0.9 ± 0.1 hours. In fed horses, maximal concentration was reduced to 0.3 ± 0.04 μg/m L with a time at maximal concentration at 1.3 ± 0.3 hours. It’s almost as if when the 4th of July festivities end, we move directly into Autumn. This blog is full of completely random stuff that I want to share with the world. But, I feel like we need another Holiday in between the two to get us through the rest of summer. and that is why this guilt-free pumpkin pie smoothie is a must-try for Fummer (that’s Fall AND Summer combined– get it? I have fun creating what I call "Instructional Pictures" about food, tips, life and more, and that's how I came up with the oh-so brilliant name "instrupix". :) This blog is full of completely random stuff that I want to share with the world. I have fun creating what I call "Instructional Pictures" about food, tips, life and more, and that's how I came up with the oh-so brilliant name "instrupix".

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