As a member of the selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant. Originally created by Eli Lilly pharmaceutical company, dapoxetine was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. Different dosage has different impacts on different types of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. 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Poxet-60 tablets are used to treat premature ejaculation (PE), which is one of the most common causes of sexual dysfunction in men. It is defined as early ejaculation with minimal sexual stimulation before of soon after penetration and can cause distress and problems with relationships. Poxet-60 is used to improve control over ejaculation and increase the time interval before ejaculation occurs during intercourse, for men with persistent or recurrent PE. Poxet-60 tablets contain dapoxetine 60mg, a selective serotonin reuptake inhibitor (SSRI) that is used specifically for premature ejaculation (PE), as it has a rapid onset of action, with maximum effect within 1-2 hours and a short half-life, which means that it is rapidly eliminated from the body within 24 hours. Ejaculation is a reflex that is mediated by the sympathetic nervous system. When sexual stimulation has reached a certain threshold, sensory nerve cells in the spinal cord are activated and nerve impulses are sent to the brain, which then send messages back to motor neurones controlling the muscles in the penis that contract to effect ejaculation. The ejaculation reflex is thought to be mediated by serotonin, a specific brain chemical or neurotransmitter that is involved is transmitting nerve signals, which enables brain cells to communicate. Clear Sky Pharmacy serves thousands of happy customers with cheap generic prescription drugs, over-the-counter medications (OTC), and original brand medicines. We focus on premium quality drugs at the lowest possible prices and we guarantee that you will always receive the same brand name exactly as presented on our site. Contact our pharmacists and customer care representatives by email [email protected] phone 1-888-9794711. 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