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Canadian International Pharmacy Association regulations you are permitted to order a. Celebrex, a prescription pain medication in the same class as Vioxx, which was pulled from the market in 2004 over cardiovascular concerns, is as safe as over-the-counter (OTC) pain medications. However, you may want to think twice before switching from Advil or Aleve to Celebrex. The somewhat surprising finding is the result of a 10-year study conducted by Pfizer, the maker of Celebrex, involving more than 24,000 people with arthritis who either had heart disease or were at high risk for it. They were given either Celebrex (celecoxib), a drug known as a COX-2 inhibitor, Advil (ibuprofen) or Aleve (naproxen). The latter two are available OTC and are known as NSAIDs (non-steroidal anti-inflammatory drugs). Although the study was funded by Pfizer, the lead author was Steven Nissen, MD, a cardiologist at the Cleveland Clinic, who was one of the first physicians to sounds alarms about links between Vioxx and an increased risk of heart attack and stroke. Published in the New England Journal of Medicine, the study not only found that all 3 medications had similar efficacy, but all had nearly the same rate of heart disease, heart attack or stroke from taking it. CELEBREX is an FDA-approved NSAID (nonsteroidal anti-inflammatory drug) used to treat the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), juvenile rheumatoid arthritis in patients 2 years and older, and ankylosing spondylitis; and for the management of acute pain in adults, and for the management of menstrual cramps. Some patients and their doctors prefer brand-name medications. 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